Interaction of Hepatitis B virus with cellular processes in liver carcinogenesis.

W H Caselmann, C Rabe

Journal: Critical reviews in clinical laboratory sciences 2001;37(5):407-29

PMID: 11078055

Abstract

Hepatitis B infection is strongly linked epidemiologically to hepatocellular carcinoma development. This article reviews the molecular mechanisms by which hepatitis B encoded proteins such as hepatitis B x and hepatitis B surface transactivators may interact with gene transcription, tumor suppression, apoptosis, and signalling pathways of the liver cell with the possible consequence of tumor induction. Data on the interaction between hepatitis B proteins and cellular processes are often conflicting indicating a non-specific simultaneous interaction with antagonistic cellular processes that result in the formation of escape mutants that are not subject to these selective pressures.

Address: Department of Medicine I, University of Bonn, Germany.

DOI: 10.1080/10408360091174277

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MeSH Terms: Amino Acid Sequence, Apoptosis, Base Sequence, Cell Transformation, Neoplastic, Cell Transformation, Viral, DNA Repair, Hepatitis B virus, Humans, Liver Neoplasms, Molecular Sequence Data, Signal Transduction, Transcriptional Activation, Viral Proteins