Perfusion CT imaging of treatment response in oncology.

Davide Prezzi, Aisha Khan, Vicky Goh

Journal: European journal of radiology 2016;84(12):2380-5

PMID: 25864440

Full Text on Elsevier Science View on PubMed

Abstract

Perfusion CT was first described in the 1970s but has become accepted as a clinical technique in recent years. In oncological practice Perfusion CT allows the downstream effects of therapies on the tumour vasculature to be monitored. From the dynamic changes in tumour and vascular enhancement following intravenous iodinated contrast agent administration, qualitative and quantitative parameters may be derived that reflect tumour perfusion, blood volume, and microcirculatory changes with treatment. This review outlines the mechanisms of action of available therapies and state-of-the-art imaging practice.

Address: Division of Imaging Sciences & Biomedical Engineering, King's College London, United Kingdom; Department of Radiology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom.; Department of Radiology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom.; Division of Imaging Sciences & Biomedical Engineering, King's College London, United Kingdom; Department of Radiology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom. Electronic address: [email protected].

DOI: 10.1016/j.ejrad.2015.03.022

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MeSH Terms: Contrast Media, Humans, Iodine, Microcirculation, Neoplasms, Radiographic Image Enhancement, Reproducibility of Results, Tomography, X-Ray Computed