Acquired Von Willebrand Syndrome In Aortic Stenosis: Case Report And Review.

Said Alsidawi, Marian Couto, Angel López-Candales

Journal: Boletin de la Asociacion Medica de Puerto Rico 2015;107(2):86-8

PMID: 26434092

Abstract

We present a case of a 61 year old man who presented with a 3 week history of easy bruising and ecchymoses in both thighs and right arm without significant trauma. Physical exam was remarkable for oozing gums, diminished second heart sound, a systolic ejection murmur at the aortic position with radiation to carotids, and delayed pulses. Laboratories were remarkable for iron deficiency anemia. Echocardiogram was consistent with severe aortic stenosis. Colonoscopy revealed several arteriovenous malformations throughout the colon. There is an association between severe aortic stenosis and gastrointestinal bleeding. The pathogenesis of Heyde's Syndrome involves iron deficiency anemia due to acquired von Willebrand factor (vWF) deficiency and ultimately gastrointestinal angiodysplasia. Correct diagnosis and management warrants a multidisciplinary approach.

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https://medlineplus.gov/gastrointestinalbleeding.h...

Miscellaneous:

https://assays.cancer.gov/non-CPTAC-3613

MeSH Terms: ADAM Proteins, ADAMTS13 Protein, Angiodysplasia, Aortic Valve Stenosis, Colonoscopy, Diabetic Nephropathies, Ecchymosis, Enzyme Activation, Gastrointestinal Hemorrhage, Humans, Hypertension, Male, Middle Aged, Protein Stability, Protein Structure, Quaternary, Shear Strength, Syndrome, Treatment Refusal, von Willebrand Diseases, von Willebrand Factor