Harnessing medically relevant metals onto water-soluble subphthalocyanines: towards bimodal imaging and theranostics.

Yann Bernhard, Pascale Winckler, Jean-Marie Perrier-Cornet, Richard A Decréau

Journal: Dalton transactions (Cambridge, England : 2003) 2015;44(7):3200-8

PMID: 25581854

Full Text on Royal Society of Chemistry View on PubMed

Abstract

Subphthalocyanine (SubPc), a putative fluorophore for optical imaging (OI), was conjugated to chelating ligands (DOTA, DTPA) affording water-soluble conjugates complexed with (non-radioactive) metals relevant to the following medical imaging techniques/therapies: MRI (Gd), PET (Cu, Ga), SPECT (In, Ga, Lu), RIT (Cu, Lu, Y), and NCT (Gd). Magneto-optical properties of ditopic gadolinium species (and optical properties of other metal containing species) were examined (brightness (ε × ΦF) and relaxivity R1) and fluorescence confocal/biphoton microscopy studies were conducted.

Address: Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB), UMR 6302 CNRS-Université de Bourgogne, BP 47870, F-21078, Dijon Cedex, France. [email protected].

DOI: 10.1039/c4dt03536d

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MeSH Terms: Cell Line, Tumor, Cell Survival, Humans, Indoles, Isoindoles, Magnetic Resonance Spectroscopy, Melanoma, Experimental, Metals, Solubility, Water