Blood-based tests for colorectal cancer screening: do they threaten the survival of the FIT test?

Dean E Brenner, Scott Kopetz, Robert S Bresalier

Journal: Digestive diseases and sciences 2015;60(3):664-71

PMID: 25680874

Abstract

Colorectal cancer is the second leading cause of cancer death in industrialized nations, accounting for 10% of the total cancer burden with an individual lifetime risk of ~6% in the USA (Siegel et al. in CA Cancer J Clin 62:9-29, 2014, American Cancer Society in Colorectal cancer facts and figures 2011-2013. American Cancer Society, Atlanta, 2011, Siegel et al. in CA Cancer J Clin 61:212-236, 2011). Although numerous screening methods have been incorporated into guidelines for colorectal cancer screening, no guideline includes a noninvasive blood-based test as a recommended option.

Address: Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1466, Houston, TX, 77030, USA, [email protected].

DOI: 10.1007/s10620-015-3575-2

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https://doi.org/10.1007/s10620-015-3575-2

MeSH Terms: Biomarkers, Colorectal Neoplasms, Humans, Immunologic Tests, Mass Screening, Occult Blood