The role of necroptosis in neurosurgical diseases.

T Liu, Y H Bao, Y Wang, J Y Jiang

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica 2015;48(4):292-8

PMID: 25714887

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Abstract

Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection after traumatic and ischemic brain injury. Therefore, the necroptotic pathway represents a potential target for neurological diseases that are managed by neurosurgeons. In this review, we summarize recent advances in the understanding of necroptotic signaling pathways and explore the role of necroptotic cell death in craniocerebral trauma, brain tumors, and cerebrovascular diseases.

Address: Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

DOI: 10.1590/1414-431X20144310

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MeSH Terms: Apoptosis, Brain Injuries, Cell Death, Cerebrovascular Disorders, Death Domain Receptor Signaling Adaptor Proteins, Humans, Hydroxycholesterols, Necrosis, Neuroprotective Agents, Receptors, Death Domain, Signal Transduction, Toll-Like Receptors