Caffeine and headache: specific remarks.

C A Espinosa Jovel, F E Sobrino Mejía

Journal: Neurologia (Barcelona, Spain) 2018;32(6):394-398

PMID: 25728949

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Abstract

Caffeine is the most widely used psychostimulant worldwide. Excessive caffeine consumption induces a series of both acute and chronic biological and physiological changes that may give rise to cognitive decline, depression, fatigue, insomnia, cardiovascular changes, and headache. Chronic consumption of caffeine promotes a pro-nociceptive state of cortical hyperexcitability that can intensify a primary headache or trigger a headache due to excessive analgesic use. This review offers an in-depth analysis of the physiological mechanisms of caffeine and its relationship with headache.

Address: Neurología, Facultad de Medicina, Universidad de la Sabana, Bogotá, Colombia; Departamento de Neurología, Hospital Occidente de Kennedy, Bogotá, Colombia. Electronic address: [email protected].; Neurología, Facultad de Medicina, Universidad de la Sabana, Bogotá, Colombia; Departamento de Neurología, Hospital Occidente de Kennedy, Bogotá, Colombia.

DOI: 10.1016/j.nrl.2014.12.016

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Medical:

https://medlineplus.gov/caffeine.html

Other Literature Sources:

https://scite.ai/reports/25728949

MeSH Terms: Caffeine, Central Nervous System Stimulants, Headache, Headache Disorders, Humans