Aminobenzoic acid incorporated octapeptides for cation transport.

Bahiru P Benke, Nandita Madhavan

Journal: Bioorganic & medicinal chemistry 2016;23(7):1413-20

PMID: 25766627

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Abstract

Robust oligopeptides that mimic natural ion channels are attractive for use as molecular switches or model systems to study ion transport. Herein, we report octapeptides derived from aminobenzoic acid and l/d amino acids. Two of the alanine containing peptides were found to be most active and the peptide containing p-aminobenzoic acid was found to be most active (2.4 times its m-analog). Experimental studies indicate the peptides do not transport halides and transport alkali metal ions.

Address: Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India.; Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India. Electronic address: [email protected].

DOI: 10.1016/j.bmc.2015.02.031

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MeSH Terms: 4-Aminobenzoic Acid, Cations, Ion Transport, Oligopeptides