Messenger proteins: homeoproteins, TAT and others.

A Prochiantz

Journal: Current opinion in cell biology 2000;12(4):400-6

PMID: 10873818

Full Text on Elsevier Science View on PubMed

Abstract

Some proteins are internalized by live cells by a process that does not involve classical endocytosis and thus gain direct access to the cytoplasm and nucleus. These same proteins are often secreted, despite the absence of a signal peptide. Recent studies of this unexpected mode of intercellular signaling have opened the way for biotechnological developments.

Address: CNRS UMR 8542, Ecole Normale Supérieure, Paris Cedex 5, 75230, France. [email protected].

DOI: 10.1016/s0955-0674(00)00108-3

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MeSH Terms: Amino Acid Sequence, Gene Products, tat, Homeodomain Proteins, Humans, Molecular Sequence Data, Signal Transduction