Lactoferrin and eosinophilic cationic protein in nasal secretions of patients with experimental rhinovirus colds, natural colds, and presumed acute community-acquired bacterial sinusitis.

M D Niehaus, J M Gwaltney, J O Hendley, M J Newman, P W Heymann, G P Rakes, T A Platts-Mills, R L Guerrant

Journal: Journal of clinical microbiology 2000;38(8):3100-2

PMID: 10921988

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Abstract

To distinguish sinusitis from uncomplicated "colds," we examined lactoferrin and eosinophilic cationic protein (ECP) in nasal secretions. Lactoferrin titers were >/=1:400 in 4% of persons with uncomplicated colds and controls but in 79% of persons with sinusitis or purulent sputa. ECP levels were >200 ng/ml in 61% of persons with colds and >3,000 ng/ml in 62% of persons with sinusitis. Nasal lactoferrin helps distinguish sinusitis from colds.

Address: Divisions of Geographic and International Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.

DOI: 10.1128/JCM.38.8.3100-3102.2000

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MeSH Terms: Bacterial Infections, Blood Proteins, Common Cold, Community-Acquired Infections, Eosinophil Granule Proteins, Humans, Lactoferrin, Mucus, Nasal Mucosa, Rhinovirus, Ribonucleases, Sinusitis