Pseudozyma spp catheter-associated blood stream infection, an emerging pathogen and brief literature review.

Wajid Siddiqui, Yasir Ahmed, Helmut Albrecht, Sharon Weissman

Journal: BMJ case reports 2015;2014():bcr2014206369

PMID: 25498807

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Abstract

Pseudozyma spp are amorphic yeasts. They are commonly plant pathogens, but rarely cause invasive fungal disease in humans. Only three cases of central venous catheter (CVC)-associated blood stream infections due to this organism have been reported in the literature. Main underlying risk factors for Pseudozyma spp infection are bowel surgery, CVC and total parenteral nutrition. We present a rare case of Pseudozyma spp catheter-associated blood stream infection that was successfully treated with antifungal therapy and removal of CVC. It is important to recognise and differentiate this species from other yeasts as it may require the use of amphotericin B or voriconazole instead of fluconazole, to which the organism is variably resistant.

2014 BMJ Publishing Group Ltd.

Address: Department of Infectious Diseases, Phoebe Putney Memorial Hospital, Albany, Georgia, USA.; Department of Internal Medicine, Texas Tech University of Health Science Center, Odessa, Texas, USA.; Department of Infectious Diseases, University of South Carolina, Columbia, South Carolina, USA.

DOI: 10.1136/bcr-2014-206369

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MeSH Terms: Amphotericin B, Antifungal Agents, Catheter-Related Infections, Catheterization, Central Venous, Central Venous Catheters, Female, Fluconazole, Fungemia, Humans, Middle Aged, Mycoses, Risk Factors, Voriconazole, Yeasts