MALT1 induced immune response is governed by miR-2909 RNomics.

Deepak Kaul, M Arora, A Garg, S Sharma

Journal: Molecular immunology 2015;64(1):210-7

PMID: 25500259

Full Text on Elsevier Science View on PubMed

Abstract

The paracaspase mucosa-associated lymphoid tissue 1 (MALT1) has been widely recognized to play crucial role in lymphocyte activation, development and the generation of lymphomas through the modulation of innate and adaptive immune responses. Our results reported here provide evidence for the first time to support the view that MALT1 exerts its effect upon immune response involving genes coding for retinoic acid-inducible gene 1 (RIG1); interferon-β (IFN-β); apo-lipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G (APOBEC3G); IFN-γ; chemokine (C-C motif) ligand 5 (CCL5) and interleukin-17 (IL-17) through the initiation of cellular miR-2909 RNomics. This ensures sustained expression of specificity protein 1 (SP1)-dependent regulation of genes that in-turn governs MALT1 induced immune response. Based upon these results, a mechanistic-pathway is proposed that links the epigenomic-interplay between MALT1 and miR-2909.

Address: Departments of Experimental Medicine and Biotechnology, Post-graduate Institute of Medical Education and Research, Sector-12, Chandigarh 160012, India. Electronic address: [email protected].; Departments of Experimental Medicine and Biotechnology, Post-graduate Institute of Medical Education and Research, Sector-12, Chandigarh 160012, India.

DOI: 10.1016/j.molimm.2014.11.018

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MeSH Terms: 5' Untranslated Regions, APOBEC-3G Deaminase, Base Sequence, Caspases, Computational Biology, Cytidine Deaminase, Gene Expression Regulation, HeLa Cells, Humans, Immunity, Immunomodulation, Immunophenotyping, Kruppel-Like Factor 4, Kruppel-Like Transcription Factors, MicroRNAs, Models, Genetic, Molecular Sequence Data, Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein, Neoplasm Proteins, RNA, Messenger