Subacute cutaneous lupus erythematosus: report of a patient who subsequently developed a meningioma and whose skin lesions were treated with isotretinoin.

T T Richardson, P R Cohen

Journal: Cutis 2001;66(3):183-8

PMID: 11006852

Abstract

Cancer has been reported in patients with systemic lupus erythematosus (SLE). A possible association of the development of hematologic malignancies in patients with SLE has been suggested. In some patients, subacute cutaneous lupus erythematosus, a distinct subset of lupus erythematosus, has appeared, resolved, or both as a solid tumor-related paraneoplastic syndrome. A woman in whom a meningioma was diagnosed 44 years following the onset of subacute cutaneous lupus erythematosus is described; her skin lesions improved after starting isotretinoin therapy. The relationship between lupus erythematosus and neoplasia is summarized and the management of subacute cutaneous lupus erythematosus with retinoids is reviewed.

Address: Department of Internal Medicine, University of Nevada, Las Vegas, USA.

MeSH Terms: Administration, Topical, Aged, Anti-Inflammatory Agents, Clobetasol, Dermatologic Agents, Female, Fluocinonide, Glucocorticoids, Humans, Isotretinoin, Lupus Erythematosus, Cutaneous, Meningeal Neoplasms, Meningioma