A comprehensive mathematical framework for modeling intestinal smooth muscle cell contraction with applications to intestinal edema.

Jennifer Young, Sevtap Ozisik, Beatrice Riviere, Muhammad Shamim

Journal: Mathematical biosciences 2016;262():206-13

PMID: 25640870

Full Text on Elsevier Science View on PubMed

Abstract

The contraction of intestinal smooth muscle cells (ISMCs) involves many coordinated biochemical and mechanical processes. In this work, we present a framework for modeling ISMC contractility that begins with chemical models of calcium dynamics, continues with myosin light chain phosphorylation and force generation, and ends with a cell model of the ISMC undergoing contraction-relaxation. The motivation for developing this comprehensive framework is to study the effects of edema (excess fluid build-up in the muscle tissue) on ISMC contractility. The hypothesis is that more fluid equates to dilution of an external stimulis, eventually leading to reduced contractility. We compare our results to experimental data collected from normal versus edematous intestinal muscle tissue.

Address: Computational and Applied Mathematics Department, Rice University, Houston, Texas 77005, USA.; Computational and Applied Mathematics Department, Rice University, Houston, Texas 77005, USA. Electronic address: [email protected].

DOI: 10.1016/j.mbs.2014.12.009

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MeSH Terms: Calcium Signaling, Computer Simulation, Edema, Humans, Intestinal Diseases, Mathematical Concepts, Models, Biological, Muscle Contraction, Muscle, Smooth, Myocytes, Smooth Muscle, Myosin Light Chains