Interferon-α combined with lamivudine versus lamivudine monotherapy for the emergence of YMDD mutations in chronic hepatitis B infection: a meta-analysis of randomized controlled trials.

Ya-li Zhang, Jie Zhang, Li-yan Cui

Journal: Hepato-gastroenterology 2015;62(137):133-9

PMID: 25911883

Abstract

BACKGROUND/AIMS

Tyrosine-methionine-aspartate-aspartate (YMDD) mutations were the main limitation of lamivudine (LAM) for treating chronic hepatitis B (CHB). The aim of this study was to evaluate whether LAM combined with IFN-α offer advantage over lamivudine monotherapy for the occurrence of YMDD mutations in CHB using a meta-analysis.

METHODOLOGY

We searched electronic databases and calculated the odds ratios (OR) with their 95% confidence intervals (CI) and pooled the results.

RESULTS

Our meta-analysis indicated that the difference of YMDD mutation rates between the combination therapy of IFN-α2b, IFN-α2a and Peg-IFN-α2a respectively plus LAM and LAM monotherapy (95% CI, 3.25-9.70, 95% CI, 5.77-17.51, 95% CI, 6.79-26.13, respectively). The rate of YMDD mutations in LAM monotherapy was increased when compared with combination and sequential combination group (95% CI, 6.79-22.16, and 95% CI, 2.69-7.75, respectively). The YMDD mutation rate in combination therapy was lower than that of LAM monotherapy in HBeAg positive patients (95% CI, 4.98-13.23).

CONCLUSIONS

Our present meta-analysis suggests that different types of IFN-a in combination with LAM can significantly reduce the rate of YMDD mutation compared to LAM monotherapy.

MeSH Terms: Antimutagenic Agents, Antiviral Agents, Chi-Square Distribution, Drug Resistance, Viral, Drug Therapy, Combination, Evidence-Based Medicine, Gene Products, pol, Genotype, Hepatitis B virus, Hepatitis B, Chronic, Humans, Interferon alpha-2, Interferon-alpha, Lamivudine, Mutation, Odds Ratio, Phenotype, Polyethylene Glycols, Randomized Controlled Trials as Topic, Recombinant Proteins, Time Factors, Treatment Outcome