Strategies of Intracellular Pathogens for Obtaining Iron from the Environment.

Nidia Leon-Sicairos, Ruth Reyes-Cortes, Alma M Guadrón-Llanos, Jesús Madueña-Molina, Claudia Leon-Sicairos, Adrian Canizalez-Román

Journal: BioMed research international 2016;2015():476534

PMID: 26120582

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Abstract

Most microorganisms are destroyed by the host tissues through processes that usually involve phagocytosis and lysosomal disruption. However, some organisms, called intracellular pathogens, are capable of avoiding destruction by growing inside macrophages or other cells. During infection with intracellular pathogenic microorganisms, the element iron is required by both the host cell and the pathogen that inhabits the host cell. This minireview focuses on how intracellular pathogens use multiple strategies to obtain nutritional iron from the intracellular environment in order to use this element for replication. Additionally, the implications of these mechanisms for iron acquisition in the pathogen-host relationship are discussed.

Address: Unidad de Investigación de la Facultad de Medicina, Universidad Autónoma de Sinaloa, Cedros y Sauces, S/N Fracc. Fresnos, 80246 Culiacán, SIN, Mexico ; Departamento de Investigación del Hospital Pediátrico de Sinaloa "Dr. Rigoberto Aguilar Pico", Boulevard Constitución S/N, Colonia Jorge Almada, 80200 Culiacán, SIN, Mexico.; Unidad de Investigación de la Facultad de Medicina, Universidad Autónoma de Sinaloa, Cedros y Sauces, S/N Fracc. Fresnos, 80246 Culiacán, SIN, Mexico.; Facultad de Medicina, Universidad Autónoma de Sinaloa, Cedros y Sauces, S/N Fracc. Fresnos, 80246 Culiacán, SIN, Mexico.; Doctorado en Biotecnología, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Sinaloa, Avenida de las Américas y Josefa Ortiz (Ciudad Universitaria), 80030 Culiacán, SIN, Mexico.

DOI: 10.1155/2015/476534

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MeSH Terms: Bacteria, Cellular Microenvironment, Cytoplasm, Host-Pathogen Interactions, Humans, Iron, Lysosomes, Macrophages, Phagocytosis