Spatial localization of ryanodine receptors in human cardiac cells.

A Vallmitjana, C Nolla, A Herraiz-Martínez, L Hove-Madsen, R Benítez

Journal: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2016;2015():6297-300

PMID: 26737732

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Abstract

["We present a novel image processing method to determine the location of ryanodine receptors in cardiac cells. A semi-automatic manual validation by an expert has been used in order to establish the performance of the segmentation method. The approach provides high accuracy under different experimental conditions and it is robust to common sources of noise including experimental, molecular and biological fluctuations."]

DOI: 10.1109/EMBC.2015.7319832

MeSH Terms: Fluorescent Antibody Technique, Indirect, Heart Atria, Humans, Image Processing, Computer-Assisted, Microscopy, Fluorescence, Myocytes, Cardiac, ROC Curve, Ryanodine Receptor Calcium Release Channel, Single-Cell Analysis