Bacterial microcompartments and the modular construction of microbial metabolism.

Cheryl A Kerfeld, Onur Erbilgin

Journal: Trends in microbiology 2015;23(1):22-34

PMID: 25455419

Full Text on Elsevier Science View on PubMed

Abstract

Bacterial microcompartments (BMCs) are protein-bound organelles predicted to be present across 23 bacterial phyla. BMCs facilitate carbon fixation as well as the aerobic and anaerobic catabolism of a variety of organic compounds. These functions have been linked to ecological nutrient cycling, symbiosis, pathogenesis, and cardiovascular disease. Within bacterial cells, BMCs are metabolic modules that can be further dissociated into their constituent structural and functional protein domains. Viewing BMCs as genetic, structural, functional, and evolutionary modules provides a framework for understanding both BMC-mediated metabolism and for adapting their architectures for applications in synthetic biology.

Address: DOE Plant Research Laboratory, Michigan State University, East Lansing, MI, USA; Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA, USA; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA; Berkeley Synthetic Biology Institute, Berkeley, CA, USA. Electronic address: [email protected].; Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA, USA.

DOI: 10.1016/j.tim.2014.10.003

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MeSH Terms: Bacteria, Bacterial Proteins, Cell Compartmentation, Protein Conformation, Protein Engineering, Synthetic Biology