Hypopituitarism after traumatic brain injury.

Eva Fernandez-Rodriguez, Ignacio Bernabeu, Ana I Castro, Felipe F Casanueva

Journal: Endocrinology and metabolism clinics of North America 2015;44(1):151-9

PMID: 25732651

Full Text on Elsevier Science View on PubMed

Abstract

The prevalence of hypopituitarism after traumatic brain (TBI) injury is widely variable in the literature; a meta-analysis determined a pooled prevalence of anterior hypopituitarism of 27.5%. Growth hormone deficiency is the most prevalent hormone insufficiency after TBI; however, the prevalence of each type of pituitary deficiency is influenced by the assays used for diagnosis, severity of head trauma, and time of evaluation. Recent studies have demonstrated improvement in cognitive function and cognitive quality of life with substitution therapy in GH-deficient patients after TBI.

Address: Endocrinology Division, Departamento de Medicina, Complejo Hospitalario Universitario de Santiago de Compostela, SERGAS, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.; Endocrinology Division, Departamento de Medicina, Complejo Hospitalario Universitario de Santiago de Compostela, SERGAS, Universidad de Santiago de Compostela, Santiago de Compostela, Spain; Research Centre in Physiopathology of Obesity and Nutrition, Instituto Salud Carlos III, Santiago de Compostela, Spain.; Endocrinology Division, Departamento de Medicina, Complejo Hospitalario Universitario de Santiago de Compostela, SERGAS, Universidad de Santiago de Compostela, Santiago de Compostela, Spain; Research Centre in Physiopathology of Obesity and Nutrition, Instituto Salud Carlos III, Santiago de Compostela, Spain. Electronic address: [email protected].

DOI: 10.1016/j.ecl.2014.10.012

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MeSH Terms: Brain Injuries, Human Growth Hormone, Humans, Hypopituitarism