Clinical utility of reticulocyte parameters.

Elisa Piva, Carlo Brugnara, Federica Spolaore, Mario Plebani

Journal: Clinics in laboratory medicine 2015;35(1):133-63

PMID: 25676377

Full Text on Elsevier Science View on PubMed

Abstract

The reticulocyte count reflects the erythropoietic activity of bone marrow and is thus useful in both diagnosing anemias and monitoring bone marrow response to therapy. Automated flow-cytometric analysis has led to a significant advance in reticulocyte counting, by simultaneously providing additional parameters and indices such as the reticulocyte immature reticulocyte fraction (IRF), the reticulocyte volume, and the hemoglobin content and concentration. IRF has been proposed as an early marker of engraftment. Reticulocyte hemoglobin content is useful in assessing the functional iron available for erythropoiesis, and reticulocyte volume is a useful indicator when monitoring the therapeutic response of anemias.

Address: Department of Laboratory Medicine, University-Hospital of Padova, Via Nicolò Giustiniani 2, 35128 Padova, Italy. Electronic address: [email protected].; Department of Laboratory Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, BA 760, Boston, MA 02115, USA.; Department of Laboratory Medicine, University-Hospital of Padova, Via Nicolò Giustiniani 2, 35128 Padova, Italy.

DOI: 10.1016/j.cll.2014.10.004

Link outs

Free resources

Other Literature Sources:

https://www.lens.org/lens/search/patent/list?q=ref...

Subscription / membership required

Full Text Sources:

MeSH Terms: History, 19th Century, History, 20th Century, History, 21st Century, Humans, Iron, Reference Values, Reticulocyte Count, Reticulocytes