DMAEM-based cationic polymers as novel carriers for DNA delivery into cells.

Iryna V Tanasienko, Alla I Yemets, Nataliya S Finiuk, Rostyslav R Stoika, Yaroslav B Blume

Journal: Cell biology international 2015;39(3):243-5

PMID: 25234366

Abstract

Different transformation systems and vectors have been improved to increase the effectiveness of transformation and achieve stable expression of target genes. Because classical direct and indirect transformation processes commonly suffer from instability of a gene in the environment, gene deletion, transgene silencing, and poor gene transfer efficiency. Nowadays, gene transformation technologies are based on the use of new carriers (nanoparticles, carbon nanotubes, whiskers, and polymers) characterized by better efficiency and reproducibility for the direct DNA delivery into cells. In this review, we have focused on the novel DMAEM-based direct DNA delivery system and its possible applications for cell transformation.

Address: Department of Genomics and Molecular Biotechnology, Institute of Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Osipovskogo St. 2a, Kyiv, 04123, Ukraine.

DOI: 10.1002/cbin.10381

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MeSH Terms: Cations, DNA, Humans, Methacrylates, Nanoparticles, Nylons, Transfection