Metabolic Response of Pediatric Traumatic Brain Injury.

Mayumi L Prins, Joyce Matsumoto

Journal: Journal of child neurology 2016;31(1):28-34

PMID: 25336427

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Abstract

Traumatic brain injury (TBI) in the pediatric brain presents unique challenges as the complex cascades of metabolic and biochemical responses to TBI are further complicated ongoing maturational changes of the developing brain. TBIs of all severities have been shown to significantly alter metabolism and hormones which impair the ability of the brain to process glucose for cellular energy. Under these conditions, the brain's primary fuel (glucose) becomes a less favorable fuel and the ability of the younger brain to revert to ketone metabolism can an advantage. This review addresses the potential of alternative substrate metabolic intervention as a logical pediatric TBI neuroprotective strategy.

Address: Department of Neurosurgery, University of California Los Angeles, Los Angeles, CA, USA Brain Injury Research Center, University of California Los Angeles, Los Angeles, CA, USA [email protected].; Department of Pediatrics, Division of Pediatric Neurology, University of California Los Angeles, Los Angeles, CA, USA.

DOI: 10.1177/0883073814549244

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MeSH Terms: Brain Injuries, Humans, Metabolic Diseases, Pediatrics