Homology-independent protein engineering.

S J Benkovic, S Lutz

Journal: Current opinion in biotechnology 2000;11(4):319-24

PMID: 10975450

Full Text on Elsevier Science View on PubMed

Abstract

Is structure, rather than sequence, the key to the successful generation of truly novel proteins? While protein evolution by homologous recombination has become an established tool to explore confined regions in sequence space, the generation of functional hybrid proteins by homology-independent methods further expands the scope of protein engineering.

Address: Department of Chemistry, The Pennsylvania State University, University Park 16802-6300, USA.

DOI: 10.1016/s0958-1669(00)00106-3

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MeSH Terms: Combinatorial Chemistry Techniques, Enzymes, Protein Engineering, Proteins, Sequence Homology, Amino Acid