Heading toward radioactive seed localization in non-palpable breast cancer surgery? A meta-analysis.

Bas Pouw, Linda J de Wit-van der Veen, Marcel P M Stokkel, Claudette E Loo, Marie-Jeanne T F D Vrancken Peeters, Renato A Valdés Olmos

Journal: Journal of surgical oncology 2015;111(2):185-91

PMID: 25195916

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Abstract

Wire-guided localization is the most commonly used technique for intraoperative localization of non-palpable breast cancer. Radioactive seed localization (RSL) is becoming more popular and seems to be a reliable alternative for intraoperative lesion localization. The purpose of the present meta-analysis was to evaluate the use of RSL. Primary study outcomes were irradicality and re-excision rates. In total 3168 patients were included. The clinical adaptation shows growing confidence in RSL and further growth is expected.

Address: Department of Nuclear Medicine, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

DOI: 10.1002/jso.23785