Chronic gastritis - an update.

Mariya Varbanova, Katrin Frauenschläger, Peter Malfertheiner

Journal: Best practice & research. Clinical gastroenterology 2015;28(6):1031-42

PMID: 25439069

Full Text on Elsevier Science View on PubMed

Abstract

Helicobacter pylori is the main aetiologic factor for chronic gastritis worldwide. The degree of inflammation and the evolution of this form of chronic gastritis can vary largely depending on bacterial virulence factors, host susceptibility factors and environmental conditions. Autoimmune gastritis is another cause of chronic inflammation in the stomach, which can occur in all age groups. This disease presents typically with vitamin B12 deficiency and pernicious anaemia. The presence of anti-parietal cell antibodies is highly specific for the diagnosis. The role of H. pylori as a trigger for autoimmune gastritis remains uncertain. Other rare conditions for chronic gastritis are chronic inflammatory conditions such as Crohn's disease or on the background of lymphocytic or collagenous gastroenteropathies.

Address: Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University of Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.; Institute of Pathology, Otto-von-Guericke University of Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.; Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University of Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany. Electronic address: [email protected].

DOI: 10.1016/j.bpg.2014.10.005

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MeSH Terms: Anemia, Pernicious, Autoantibodies, Autoantigens, Autoimmune Diseases, Chronic Disease, Gastritis, Helicobacter Infections, Helicobacter pylori, Humans, Parietal Cells, Gastric, Vitamin B 12 Deficiency