Cross-colonization of infants with probiotic organisms in a neonatal unit.

L Hickey, S M Garland, S E Jacobs, C P F O'Donnell, S N Tabrizi

Journal: The Journal of hospital infection 2015;88(4):226-9

PMID: 25447201

Full Text on Elsevier Science View on PubMed

Abstract

This study aimed to assess probiotic cross-colonization between infants in a neonatal unit where probiotics were being administered to preterm infants during a clinical trial. We tested stool samples from all infants present in the unit at two time points; the first was during the trial and the second was after trial completion. Samples from 43 infants were tested during the trial; all five infants receiving probiotics and three of 38 not receiving probiotics were colonized. Only one of 44 infants tested after the trial was colonized. The rate of cross-colonization was lower than in previous probiotic studies.

Address: Department of Neonatal Medicine, Royal Children's Hospital, Parkville, Victoria, Australia; School of Medicine & Medical Science, University College Dublin, Ireland; Neonatal Services, Royal Women's Hospital, Parkville, Victoria, Australia. Electronic address: [email protected].; The Women's Centre for Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia; Department of Microbiology, Royal Children's Hospital, Parkville, Victoria, Australia; Infection and Immunity Group, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.; Neonatal Services, Royal Women's Hospital, Parkville, Victoria, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia; Infection and Immunity Group, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia; Neonatal Research Group, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.; School of Medicine & Medical Science, University College Dublin, Ireland; The National Maternity Hospital, Holles Street, Dublin, Ireland.

DOI: 10.1016/j.jhin.2014.09.006

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MeSH Terms: Feces, Humans, Infant, Infant, Newborn, Infant, Premature, Microbiota, Nurseries, Hospital, Probiotics, Tertiary Care Centers