Novel non-surgical prenatal approaches to treating congenital diaphragmatic hernia.

Cerine Jeanty, Shaun M Kunisaki, Tippi C MacKenzie

Journal: Seminars in fetal & neonatal medicine 2015;19(6):349-56

PMID: 25456754

Full Text on Elsevier Science View on PubMed

Abstract

This review focuses on the emerging field of non-surgical in-utero therapies in the management of fetal pulmonary hypoplasia and pulmonary hypertension associated with congenital diaphragmatic hernia (CDH). These experimental approaches include pharmacologic as well as stem-cell-based strategies. Current barriers of non-surgical therapies toward clinical translation are emphasized. As the severity of CDH will likely influence the efficacy of any in-utero therapy, the current status of prenatal imaging and the role of novel biomarkers, especially those related to fetal inflammation, are also reviewed.

Address: Department of Surgery, University of California San Francisco, CA, USA; Eli and Edythe Broad Center of Regeneration Medicine, University of California San Francisco, CA, USA.; Department of Surgery, C.S. Mott Children's Hospital, University of Michigan Health System, Ann Arbor, MI, USA.; Department of Surgery, University of California San Francisco, CA, USA; Eli and Edythe Broad Center of Regeneration Medicine, University of California San Francisco, CA, USA. Electronic address: [email protected].

DOI: 10.1016/j.siny.2014.09.007

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MeSH Terms: Antioxidants, Female, Fetal Therapies, Hernias, Diaphragmatic, Congenital, Humans, Lung, Pregnancy, Prenatal Diagnosis, Stem Cell Transplantation, Steroids, Vitamin A