Iron and copper in male reproduction: a double-edged sword.

Eva Tvrda, Rohan Peer, Suresh C Sikka, Ashok Agarwal

Journal: Journal of assisted reproduction and genetics 2015;32(1):3-16

PMID: 25245929

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Abstract

Iron and copper are essential trace nutrients playing important roles in general health and fertility. However, both elements are highly toxic when accumulating in large quantities. Their direct or indirect impact on the structure and function of male gonads and gametes is not completely understood yet. Excess or deficiency of either element may lead to defective spermatogenesis, reduced libido, and oxidative damage to the testicular tissue and spermatozoa, ultimately leading to fertility impairment. This review will detail the complex information currently available on the dual roles iron and copper play in male reproduction.

Address: Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

DOI: 10.1007/s10815-014-0344-7

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https://doi.org/10.1007/s10815-014-0344-7

MeSH Terms: Copper, Fertility, Germ Cells, Gonads, Humans, Iron, Male, Reproductive Techniques, Assisted, Spermatogenesis, Trace Elements, Zinc