Leptomeningeal failure of retinoblastoma.

Arnold Markoe, Peter A S Johnstone, Amber Orman

Journal: Pediatric blood & cancer 2015;62(3):533-5

PMID: 25262657

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Abstract

Leptomeningeal (LM) failure of retinoblastoma (Rb) has not previously been reported. Upon review of our institutional experience of external beam radiotherapy (EBRT) for Rb, we found three LM failures. We sought to better define the clinical parameters of this type of recurrence. All children with LM failure had Reese-Ellsworth stage Vb eyes. Otherwise, no variables were significantly associated with LM failure. We theorize that this phenomenon is a function of the late-stage eyes for which EBRT is being reserved in the modern era.

Address: Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida.

DOI: 10.1002/pbc.25244

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MeSH Terms: Child, Child, Preschool, Female, Humans, Male, Meningeal Neoplasms, Neoplasm Staging, Proton Therapy, Retinoblastoma