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LOXL1-associated candidate epithelial pathomechanisms in exfoliation glaucoma.

Rozalia Laczko, Kornelia M Szauter, Katalin Csiszar

Journal: Journal of glaucoma 2015;23(8 Suppl 1):S43-7

PMID: 25275905

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Abstract

Results of the present study support ocular epithelia-specific LOXL1 functions in exfoliation glaucoma that may include both dysregulated extracellular matrix cross-linking activity and cellular mechanisms involving a role for LOXL1, in direct interaction with Snail1, in promoting epithelial to mesenchymal transition and a potential shift towards fibrogenic epithelial cell phenotypes.

Address: John A. Burns School of Medicine, University of Hawaii, Honolulu, HI.
DOI: 10.1097/IJG.0000000000000105

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MeSH Terms: Amino Acid Oxidoreductases, Epithelial Cells, Epithelial-Mesenchymal Transition, Exfoliation Syndrome, Extracellular Matrix, Glaucoma, Open-Angle, Humans
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