Enzymatic aspects in ENT cancer-Matrix metalloproteinases.

A A Zamfir Chiru, C R Popescu, D C Gheorghe

Journal: Journal of medicine and life 2015;7(3):379-80

PMID: 25408759

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Abstract

The study of ENT cancer allows the implementation of molecular biology methods in diagnosis, predicting the evolution of the disease and suggesting a certain treatment. MMPs are proteolytic enzymes, zinc dependent endopeptidases, secreted by tissues and proinflammatory cells that play a role in the clearance of cell surface receptors. They are expressed as zymogens (inactive forms). Proteolytic enzymes cleave zymogens generating active forms. They are involved in cell proliferation, adhesion, differentiation, migration, angiogenesis, apoptosis and host defense.

Address: "Grigore Alexandrescu" Hospital, Bucharest, Romania.; "Colțea" Hospital, Bucharest, Romania.; "MS Curie" Hospital, Bucharest, Romania.

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https://assays.cancer.gov/non-CPTAC-3848

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-NT5E-1

MeSH Terms: Angiogenesis Inducing Agents, Carcinoma, Squamous Cell, Extracellular Matrix, Focal Adhesion Protein-Tyrosine Kinases, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Humans, Matrix Metalloproteinase Inhibitors, Matrix Metalloproteinases, Molecular Biology, Otorhinolaryngologic Neoplasms