microRNA regulation of lipoprotein metabolism.

Leigh Goedeke, Juan F Aranda, Carlos Fernández-Hernando

Journal: Current opinion in lipidology 2015;25(4):282-8

PMID: 24978143

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Abstract

PURPOSE OF REVIEW

The objective of this review article is to summarize the recent findings about the importance of microRNAs (miRNAs) in regulating lipoprotein metabolism. We highlight the recent findings that uncover the importance of miRNAs in controlling plasma LDL-cholesterol (LDL-C) levels.

RECENT FINDINGS

In 2013, several studies reported a number of miRNAs that regulate plasma LDL-C levels, including miR-30c. In this review article, we discuss those miRNAs that modulate LDL-C levels and lipoprotein secretion. We also discuss the numerous studies that demonstrate the critical role of miRNAs in governing the many facets of HDL metabolism, such as the ATP transporters, ABCA1, and ABCG1, and the scavenger receptor, SRB1.

SUMMARY

The understanding of how these miRNAs modulate lipoprotein metabolism promises to reveal new therapeutic targets to treat dyslipidemias and related cardiovascular disorders.

Address: aVascular Biology and Therapeutics Program bIntegrative Cell Signaling and Neurobiology of Metabolism Program, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut cDepartment of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.

DOI: 10.1097/MOL.0000000000000094

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MeSH Terms: ATP Binding Cassette Transporter 1, Cholesterol, Gene Expression Regulation, Humans, Lipoproteins, MicroRNAs, Scavenger Receptors, Class B