Microbial-catalyzed biotransformation of multifunctional triterpenoids derived from phytonutrients.

Syed Adnan Ali Shah, Huey Ling Tan, Sadia Sultan, Muhammad Afifi Bin Mohd Faridz, Mohamad Azlan Bin Mohd Shah, Sharifah Nurfazilah, Munawar Hussain

Journal: International journal of molecular sciences 2015;15(7):12027-60

PMID: 25003642

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Abstract

Microbial-catalyzed biotransformations have considerable potential for the generation of an enormous variety of structurally diversified organic compounds, especially natural products with complex structures like triterpenoids. They offer efficient and economical ways to produce semi-synthetic analogues and novel lead molecules. Microorganisms such as bacteria and fungi could catalyze chemo-, regio- and stereospecific hydroxylations of diverse triterpenoid substrates that are extremely difficult to produce by chemical routes. During recent years, considerable research has been performed on the microbial transformation of bioactive triterpenoids, in order to obtain biologically active molecules with diverse structures features. This article reviews the microbial modifications of tetranortriterpenoids, tetracyclic triterpenoids and pentacyclic triterpenoids.

Address: Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia. [email protected].; Faculty of Chemical Engineering, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor Darul Ehsan, Malaysia. [email protected].; Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia. [email protected].; Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia. [email protected].; Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia. [email protected].; Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia. [email protected].; Department of Basic Sciences, DHA Suffa University, Off, Khayaban-e-Tufail, Phase VII (Extension), DHA, Karachi 75500, Pakistan. [email protected].

DOI: 10.3390/ijms150712027

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MeSH Terms: Bacteria, Biotransformation, Crops, Agricultural, Fungi, Limonins, Triterpenes