Influenza vaccine as prevention for cardiovascular diseases: possible molecular mechanism.

Veljko Veljkovic, Sanja Glisic, Nevena Veljkovic, Tijana Bojic, Ursula Dietrich, Vladimir R Perovic, Alfonso Colombatti

Journal: Vaccine 2015;32(48):6569-75

PMID: 25045818

Full Text on Elsevier Science View on PubMed

Abstract

Despite plausible evidence for beneficial effects of the vaccination against influenza in cardiovascular diseases (CVD) very limited studies have been carried out to explain the molecular mechanism of this phenomenon. Using the informational spectrum method (ISM), a virtual spectroscopy method for analysis of protein-protein interactions, the bradykinin 2 receptor (BKB2R) was identified as a principal host protein which could mediate molecular processes underlying the cardioprotective effect of influenza vaccines. Based on this finding we suggest that some antibodies elicited by influenza vaccines act as agonists, which activate a BKB2R-associated signaling pathway contributing to the protection against CVD. The ISM analysis of 14 influenza viruses, which were used as components of seasonal vaccines, revealed four vaccine viruses A/Beijing/262/95(H1N1), A/NewCaledonia/20/1999(H1N1), A/Christchurch/28/2003(H3N2) and A/Perth/16/2009(H3N2), which could be suited best for further studies on the cardioprotective effect of influenza vaccines.

Address: Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, Belgrade, Serbia. Electronic address: [email protected].; Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, Belgrade, Serbia.; Laboratory of Radiobiology and Molecular Genetics, Institute of Nuclear Sciences Vinca, University of Belgrade, Belgrade, Serbia.; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, D-60596 Frankfurt-am-Main, Germany.; Divisione di Oncologia Sperimentale, Centro di Riferimento Oncologico CRO-IRCCS, 33081 Aviano, Italy.

DOI: 10.1016/j.vaccine.2014.07.007

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MeSH Terms: Antibodies, Viral, Cardiovascular Diseases, Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza Vaccines, Protein Interaction Mapping, Receptor, Bradykinin B2, Signal Transduction