A rare association of celiac disease and aplastic anemia: case report of a child and review of literature.

Rama Kumari Badyal, Man Updesh Singh Sachdeva, Neelam Varma, Babu Ram Thapa

Journal: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2015;17(6):470-3

PMID: 25075625

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Abstract

An association between severe aplastic anemia and other autoimmune diseases is rare and has been described in adults for eosinophilic fasciitis, thymomas, systemic lupus erythematosus, and thyroid disorders. Herein we report a patient with celiac disease who was not strictly following a gluten-free diet and presented with progressive pallor, fever, and weakness of 1 month's duration. On investigation, he had pancytopenia, which on subsequent evaluation revealed aplastic anemia. An association between aplastic anemia and celiac disease has rarely been reported. To the best of author's knowledge, only 1 pediatric case of celiac disease associated with aplastic anemia has been published. This is the second report to suggest such an association in children.

Address: 1 Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

DOI: 10.2350/14-05-1489-CR.1

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MeSH Terms: Anemia, Aplastic, Antilymphocyte Serum, Blood Transfusion, Bone Marrow Examination, Celiac Disease, Child, Diet, Gluten-Free, Fatal Outcome, Humans, Male, Medication Adherence, Steroids, Time Factors, Treatment Outcome