A review on lecithin:cholesterol acyltransferase deficiency.

Ramesh Saeedi, Min Li, Jiri Frohlich

Journal: Clinical biochemistry 2016;48(7-8):472-5

PMID: 25172171

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Abstract

Lecithin cholesterol acyl transferase (LCAT) is a plasma enzyme which esterifies cholesterol, and plays a key role in the metabolism of high-density lipoprotein cholesterol (HDL-C). Genetic disorders of LCAT are associated with lipoprotein abnormalities including low levels of HDL-C and presence of lipoprotein X, and clinical features mainly corneal opacities, changes in erythrocyte morphology and renal failure. Recombinant LCAT is being developed for the treatment of patients with LCAT deficiency.

Address: Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, Canada. Electronic address: [email protected].; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, Canada. Electronic address: [email protected].; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, Canada. Electronic address: [email protected].

DOI: 10.1016/j.clinbiochem.2014.08.014