Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels.

Alistair J P Brown, Gordon D Brown, Mihai G Netea, Neil A R Gow

Journal: Trends in microbiology 2015;22(11):614-22

PMID: 25088819

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Abstract

Metabolism is integral to the pathogenicity of Candida albicans, a major fungal pathogen of humans. As well as providing the platform for nutrient assimilation and growth in diverse host niches, metabolic adaptation affects the susceptibility of C. albicans to host-imposed stresses and antifungal drugs, the expression of key virulence factors, and fungal vulnerability to innate immune defences. These effects, which are driven by complex regulatory networks linking metabolism, morphogenesis, stress adaptation, and cell wall remodelling, influence commensalism and infection. Therefore, current concepts of Candida-host interactions must be extended to include the impact of metabolic adaptation upon pathogenicity and immunogenicity.

Address: Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK. Electronic address: [email protected].; Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK.; Departments of Medicine, Radboud University Nijmegen Medical Center, Nijmegen and Radboud Center for Infectious Diseases, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands.

DOI: 10.1016/j.tim.2014.07.001

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MeSH Terms: Adaptation, Physiological, Candida albicans, Host-Pathogen Interactions, Humans