Keratan sulfate: an up-to-date review.

Vitor H Pomin

Journal: International journal of biological macromolecules 2015;72():282-9

PMID: 25179279

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Abstract

Keratan sulfate (KS) is a glycosaminoglycan (GAG) type consisted of a sulfated poly-N-acetyl lactosamine chain. Besides acting as a constitutive molecule of the extracellular matrices, this GAG also plays a role as a hydrating and signaling agent in cornea and cartilage tissues. Inasmuch, KS is widely explored in the pharmaceutical industry. This review will cover the major achievements described in the literature of 2010-2014 concerning this GAG. Discussion about KS' roles in physiopathological conditions, as target or therapeutic molecule in diseases, methods of analysis and detection as well as KS-related enzymes, metabolism and developmental biology is properly provided.

Address: Program of Glycobiology, Institute of Medical Biochemistry Leopoldo de Meis, and University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-913, Brazil. Electronic address: [email protected].

DOI: 10.1016/j.ijbiomac.2014.08.029

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MeSH Terms: Cartilage, Cornea, Extracellular Matrix, Glycosaminoglycans, Humans, Inflammation, Keratan Sulfate, Ophthalmic Solutions