Higher vaspin levels in subjects with obesity and type 2 diabetes mellitus: a meta-analysis.

Rennan Feng, Yanchuan Li, Cheng Wang, Chao Luo, Liyan Liu, Fuchuan Chuo, Qiang Li, Changhao Sun

Journal: Diabetes research and clinical practice 2014;106(1):88-94

PMID: 25151227

Full Text on Elsevier Science View on PubMed

Abstract

AIMS

Visceral adipose tissue-derived serpin (vaspin) was identified as a new adipocytokine. Many studies reported vaspin concentrations in obese subjects and type 2 diabetes mellitus (T2DM) patients. However, large variation in levels of vaspin seen in different studies may be attributable to differences of sample size. The aim of this study is to establish an accurate confidence interval of vaspin levels in obese subjects and T2DM patients using a large-scale meta-analysis.

METHODS

Publications of the association between vaspin and obesity and T2DM in the databases of Medline, PubMed and EMBase were collected. The keywords included "vaspin" and "visceral adipose tissue-derived serpin". Review manager 5.0 was used to process the data.

RESULTS

For the analysis of obesity, 6 studies with 1826 participants were included in our meta-analysis; the level of vaspin was 0.52ng/ml [95% confidence interval (CI)](0.10-0.93, P=0.02) higher in obese subjects than that in non-obese healthy controls. Eleven studies with 1570 patients were included for the analysis of T2DM; the level of vaspin was 0.36ng/ml [95%CI] (0.23-0.49, P<0.00001) higher compared with that in healthy controls.

CONCLUSIONS

Significantly higher levels of serum vaspin were observed in obese subjects and T2DM patients.

Address: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China; National Key Discipline, School of Public Health, Harbin Medical University, Harbin, China.; Environmental Hygiene, School of Public Health, Harbin Medical University, Harbin, China.; STD & AIDS Center, Harbin Center for Disease Control and Prevention, Harbin, China.; Department of Endocrine and metabolism, Second Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address: [email protected].; Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China; National Key Discipline, School of Public Health, Harbin Medical University, Harbin, China. Electronic address: [email protected].

DOI: 10.1016/j.diabres.2014.07.026

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MeSH Terms: Diabetes Mellitus, Type 2, Humans, Obesity, Serpins