Biotransformation of monoterpenoids and their antimicrobial activities.

Haq Nawaz Bhatti, Saleha Suleman Khan, Ajmal Khan, Mubeen Rani, Viqar Uddin Ahmad, Muhammad Iqbal Choudhary

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 2015;21(12):1597-626

PMID: 25442268

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Abstract

Biotransformation is an economically and ecologically viable technology which has been used extensively to modify the structures of many classes of biologically active products. The discovery of novel antimicrobial metabolites from biotransformation is an important alternative to overcome the increasing levels of drug resistance by plant and human pathogens. Monoterpenes, the main constituents of essential oils, are known for their antimicrobial activities. In 2004, Farooq, Atta-Ur-Rahman and Choudhary published a review on fungal transformation of monoterpenes which covers papers published up to 2002. The present review not only updates the previous one but also discusses the antimicrobial activities (antibacterial, antifungal and antiviral) of biotransformed compounds.

Address: Department of Chemistry, University of Agriculture, Faisalabad, Pakistan. Electronic address: [email protected].; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address: [email protected].

DOI: 10.1016/j.phymed.2014.05.011

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MeSH Terms: Anti-Infective Agents, Biotransformation, Fungi, Monoterpenes