Role of soluble adenylyl cyclase in mitochondria.

Federica Valsecchi, Csaba Konrad, Giovanni Manfredi

Journal: Biochimica et biophysica acta 2015;1842(12 Pt B):2555-60

PMID: 24907564

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Abstract

The soluble adenylyl cyclase (sAC) catalyzes the conversion of ATP into cyclic AMP (cAMP). Recent studies have shed new light on the role of sAC localized in mitochondria and its product cAMP, which drives mitochondrial protein phosphorylation and regulation of the oxidative phosphorylation system and other metabolic enzymes, presumably through the activation of intra-mitochondrial PKA. In this review article, we summarize recent findings on mitochondrial sAC activation by bicarbonate (HCO(3)(-)) and calcium (Ca²⁺) and the effects on mitochondrial metabolism. We also discuss putative mechanisms whereby sAC-mediated mitochondrial protein phosphorylation regulates mitochondrial metabolism. This article is part of a Special Issue entitled: The role of soluble adenylyl cyclase in health and disease.

Address: Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, USA.; Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, USA. Electronic address: [email protected].

DOI: 10.1016/j.bbadis.2014.05.035

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MeSH Terms: Adenylyl Cyclases, Cyclic AMP-Dependent Protein Kinases, Enzyme Activation, Humans, Mitochondria, Oxidative Phosphorylation