The adaptor hypothesis revisited.

M Ibba, H D Becker, C Stathopoulos, D L Tumbula, D Söll

Journal: Trends in biochemical sciences 2000;25(7):311-6

PMID: 10871880

Full Text on Elsevier Science View on PubMed

Abstract

As originally postulated in Crick's Adaptor hypothesis, the faithful synthesis of proteins from messenger RNA is dependent on the presence of perfectly acylated tRNAs. The hypothesis also suggested that each aminoacyl-tRNA would be made by a unique enzyme. Recent data have now forced a revision of this latter point, with an increasingly diverse array of enzymes and pathways being implicated in aminoacyl-tRNA synthesis. These unexpected findings have far-reaching implications for our understanding of protein synthesis and its origins.

Address: Center for Biomolecular Recognition, Dept of Medical Biochemistry and Genetics, Laboratory B, The Panum Institute, Blegdamsvej 3c, DK-2200, Copenhagen N, Denmark.

DOI: 10.1016/s0968-0004(00)01600-5

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MeSH Terms: Amino Acyl-tRNA Synthetases, Archaeal Proteins, Evolution, Molecular, Lysine-tRNA Ligase, Models, Genetic, Phylogeny, Protein Biosynthesis, RNA, Transfer, Amino Acid-Specific, Substrate Specificity