Hepatic neoplasms in children: a focus on differential diagnosis.

Antal Dezsőfi, Valerie McLin, Nedim Hadzic

Journal: Clinics and research in hepatology and gastroenterology 2015;38(4):399-402

PMID: 24947873

Full Text on Elsevier Science View on PubMed

Abstract

Paediatric hepatic neoplasias are rare, accounting for 1-4% of all solid childhood tumors. Liver tumors in children can be classified into benign or malignant; some of the benign lesions can have the potential of malignant transformation. Two-thirds of liver tumors in children are malignant. Hepatoblastoma accounts for two-thirds of malignant liver tumors in children. Other liver malignancies in children include sarcomas, germ cell and rhabdoid tumours, and hepatocellular carcinoma. Benign tumors of the liver in children include vascular tumours, hamartomas, adenomas, and focal nodular hyperplasia. The histology and anatomy of a paediatric liver tumour guides the treatment and prognosis. Although benign and malignant liver masses share some clinical manifestations, treatment and prognosis differ.

Address: First Department of Paediatrics, Semmelweis University, Bókay János utca 53, 1083 Budapest, Hungary. Electronic address: [email protected].; Swiss Center for Liver Disease in Children, University Hospital of Geneva, Geneva, Switzerland.; Paediatric Centre for Hepatology, Gastroenterology and Nutrition, King's College Hospital, London, UK.

DOI: 10.1016/j.clinre.2014.05.001

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MeSH Terms: Child, Diagnosis, Differential, Humans, Liver Neoplasms