Left ventricular assist device-induced reverse ventricular remodeling.

D Burkhoff, J W Holmes, J Madigan, A Barbone, M C Oz

Journal: Progress in cardiovascular diseases 2000;43(1):19-26

PMID: 10935554

Free Full Text on Elsevier Science View on PubMed

Abstract

Left ventricular assist devices provide chronic pressure and volume unloading of the dilated left ventricle in patients with end-stage heart failure. This is associated with reverse structural remodeling (normalization of the passive pressure-volume relationship), reverse molecular remodeling (increased expression of several genes involved in calcium metabolism that are down-regulated in heart failure), improved baseline contractility, and improved contractile response to increased heart rate and to beta-agonist stimulation. These findings indicate the profound degree of recovery of myocardial properties in hearts previously considered to have invincible end-stage heart failure.

Address: Department of Medicine, Columbia University, New York, NY 10032, USA. [email protected]

DOI: 10.1053/pcad.2000.7190

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MeSH Terms: Calcium, Calcium-Transporting ATPases, Echocardiography, Heart Failure, Heart Ventricles, Heart-Assist Devices, Humans, Myocardial Contraction, Myocardium, Sodium-Calcium Exchanger, Ventricular Pressure, Ventricular Remodeling