Copper mediated neurological disorder: visions into amyotrophic lateral sclerosis, Alzheimer and Menkes disease.

Anami Ahuja, Kapil Dev, Ranjeet S Tanwar, Krishan K Selwal, Pankaj K Tyagi

Journal: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2015;29():11-23

PMID: 24975171

Full Text on Elsevier Science View on PubMed

Abstract

Copper (Cu) is a vital redox dynamic metal that is possibly poisonous in superfluous. Metals can traditionally or intricately cause propagation in reactive oxygen species (ROS) accretion in cells and this may effect in programmed cell death. Accumulation of Cu causes necrosis that looks to be facilitated by DNA damage, followed by activation of P53. Cu dyshomeostasis has also been concerned in neurodegenerative disorders such as Alzheimer, Amyotrophic lateral sclerosis (ALS) or Menkes disease and is directly related to neurodegenerative syndrome that usually produces senile dementia. These mortal syndromes are closely related with an immense damage of neurons and synaptic failure in the brain. This review focuses on copper mediated neurological disorders with insights into amyotrophic lateral sclerosis, Alzheimer and Menkes disease.

Address: Department of Biotechnology, NIMS University, Jaipur, India. Electronic address: [email protected].; Faculty of Medicine in Hradec Kralove, University of Charles, Prague, Czech Republic.; Department of Biotechnology, N.C. College of Engineering, Israna, India.; Department of Biotechnology, Deenbandhu Chotu Ram University of Science and Technology, Murthal, India.; Department of Biotechnology, Meerut Institute of Engineering and Technology, Meerut, India.

DOI: 10.1016/j.jtemb.2014.05.003