Association between cytosolic serine hydroxymethyltransferase (SHMT1) gene polymorphism and cancer risk: a meta-analysis.

Qianqian Wang, Kai Lu, Haina Du, Qian Zhang, Tao Chen, Yongqian Shu, Yibing Hua, Lingjun Zhu

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015;68(6):757-62

PMID: 25194438

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

The serine hydroxymethyltransferase (SHMT1) is the key enzyme in the folate metabolic pathway to provide one-carbon unit that plays an important role in biosynthesis. Abnormal biosynthesis involved in DNA synthesis and methylation can lead to activation of oncogenes and inactivation of tumor suppressor genes. And the abnormal biosynthesis is closely related to a variety of common tumors' occurrence and development. A SNP in SHMT1 C1420T may effect the procession of biosynthesis and finally influence cancer occurrence.

METHODS

Comprehensive searches were performed on PubMed and EMBASE database. We used odds ratio (OR) and 95% confidence interval (95% CI) to assess the strength of associations between SHMT1 C1420T polymorphism and cancer risk. Q-test, I(2), and funnel plot were used to assess the heterogeneity and publication bias.

RESULTS

Totally, 19 studies containing 9799 cases and 11,841 controls were performed in this meta-analysis. The results showed that there was no association between SHMT1 C1420T polymorphism and cancer risk. But in the subgroup analysis, the significant associations were found in colorectal cancer and Asian population. Publication bias was not observed in the analysis.

CONCLUSIONS

Our results indicate that the SHMT1 C1420T polymorphism do not have a significant association with the risk of cancer overall. Otherwise, SHMT1 C1420T polymorphism may have a protective effect on colorectal cancer and Asian population.

Address: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300, GuangZhou Road, Nanjing 210029, China. Electronic address: [email protected].; Department of Colorectal Surgery, The First Affiliated Hospital of Nanjing Medical University, 300, GuangZhou Road, Nanjing 210029, China. Electronic address: [email protected].; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300, GuangZhou Road, Nanjing 210029, China. Electronic address: [email protected].; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300, GuangZhou Road, Nanjing 210029, China. Electronic address: [email protected].; Department of Colorectal Surgery, The First Affiliated Hospital of Nanjing Medical University, 300, GuangZhou Road, Nanjing 210029, China. Electronic address: [email protected].; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300, GuangZhou Road, Nanjing 210029, China. Electronic address: [email protected].; Department of Colorectal Surgery, The First Affiliated Hospital of Nanjing Medical University, 300, GuangZhou Road, Nanjing 210029, China. Electronic address: [email protected].; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300, GuangZhou Road, Nanjing 210029, China. Electronic address: [email protected].

DOI: 10.1016/j.biopha.2014.08.002

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MeSH Terms: Case-Control Studies, Genetic Predisposition to Disease, Glycine Hydroxymethyltransferase, Humans, Neoplasms, Polymorphism, Genetic