Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study.

W Gehring, M Gloor

Journal: Arzneimittel-Forschung 2000;50(7):659-63

PMID: 10965426

Full Text on Georg Thieme Verlag Stuttgart, New York View on PubMed

Abstract

In a randomized, double-blind, placebo-controlled study the effect of topical dexpanthenol (CAS 81-13-0) formulated in two different lipophilic vehicles on epidermal barrier function in vivo was carried out. Seven days' treatment with dexpanthenol improved stratum corneum hydration and reduced transepidermal water loss. Active treatment was statistically different from the vehicle control on both measures. Our results suggest that topical dexpanthenol formulated in either lipophilic vehicle stabilizes the skin barrier function.

Address: Department of Dermatology, Klinikum der Stadt Karlsruhe gGmbH, Germany.

DOI: 10.1055/s-0031-1300268

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MeSH Terms: Administration, Topical, Adult, Blood-Air Barrier, Chemistry, Pharmaceutical, Double-Blind Method, Electric Conductivity, Epidermis, Female, Humans, Male, Middle Aged, Pantothenic Acid, Water Loss, Insensible