Expression of fibroblast specific protein-1 in pleural tuberculosis and its clinical biological significance.

Zhong-min Sun, Fei-yan Li, Lei Wang, Hong-yan Wang, Yuan Deng, Yan Yao

Journal: World journal of surgical oncology 2015;12():151

PMID: 24885536

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Abstract

BACKGROUND

Fibroblast specific protein-1 (S100A4) is related with many fibrotic diseases, but its role in the pathogenesis of pleural fibrosis has not been fully elucidated. Then we aim to investigate the expression and effect of fibroblast specific protein-1 (S100A4) in pleural tuberculosis and, subsequently, pleural fibrosis.

METHODS

The expression of S100A4 in pleura was examined in 30 patients with pleural tuberculosis and 5 control (disease-free) patients by immunohistochemistry using the streptavidin-peroxidase (S-P) conjugated method.

RESULTS

The expression of S100A4 in pleura was mainly distributed in the nucleus and cytoplasm of fibroblasts and vascular endothelial cells, and the positive rate was 90.0% (27 out of 30 patients with pleural tuberculosis). There were no expressions of S100A4 in the control group. In the pleura of all 30 patients with pleural tuberculosis, S100A4 had a higher expression in the two- to eight-week duration of the disease.

CONCLUSIONS

S100A4 plays an important role in the phenotypic transformation of pleural mesothelial cells and the development of pleural fibrosis.

Address: Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, No, 277 Yanta West Road, Xi'an, Shaanxi 710061, People's Republic of China. [email protected].

DOI: 10.1186/1477-7819-12-151

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https://antibodies.cancer.gov/detail/CPTC-S100A4-1

MeSH Terms: Adolescent, Adult, Biomarkers, Tumor, Case-Control Studies, Cell Nucleus, Cytoplasm, Double-Blind Method, Endothelium, Vascular, Epithelial Cells, Female, Fibroblasts, Fibrosis, Follow-Up Studies, Humans, Immunoenzyme Techniques, Male, Middle Aged, Neoplasm Staging, Pleura, Prognosis, S100 Calcium-Binding Protein A4, S100 Proteins, Survival Rate, Tuberculosis, Pleural, Young Adult