The effects of wet cupping on serum high-sensitivity C-reactive protein and heat shock protein 27 antibody titers in patients with metabolic syndrome.

Seyed Kazem Farahmand, Li Zhi Gang, Seyed Ahmad Saghebi, Maryam Mohammadi, Shabnam Mohammadi, Ghazaleh Mohammadi, Gordan A Ferns, Majid Ghanbarzadeh, Gholamreza Ghayour Razmgah, Zahra Ramazani, Majid Ghayour-Mobarhan, Habibollah Esmaily, Hamidreza Bahrami Taghanaki, Hoda Azizi

Journal: Complementary therapies in medicine 2015;22(4):640-4

PMID: 25146067

Full Text on Elsevier Science View on PubMed

Abstract

INTRODUCTION

It has previously been reported that increased level of serum heat shock proteins (Hsps) antibody in patients with metabolic syndrome. It is possible that the expression of Hsp and inflammatory markers can be affected by cupping and traditional Chinese medicine. There is a little data investigating the effects of cupping on markers of inflammation and Hsp proteins, hence, the objective of this study was evaluation of the effects of wet cupping on serum high-sensitivity C-reactive protein (hs-CRP) and Hsp27 antibody titers in patients with metabolic syndrome.

SUBJECTS AND METHODS

Serum Hs-CRP and Hsp27 antibody titers were assessed in samples from 126 patients with metabolic syndrome (18-65 years of age) at baseline, and after 6 and 12 weeks after treatment. One hundred and twenty-six patients were randomly divided into the experimental group treated with wet cupping combined with dietary advice, and the control group treated with dietary advice alone using a random number table. Eight patients in case group and five subjects in control groups were excluded from the study. Data were analyzed using SPSS 15.0 software and a repeated measure ANCOVA.

RESULTS

Serum hs-CRP titers did not change significantly between groups (p>0.05) and times (p=0.27). The same result was found for Hsp27 titers (p>0.05).

CONCLUSION

Wet-cupping on the interscapular region has no effect on serum hs-CRP and Hsp27 patients with metabolic syndrome.

Address: Department of Traditional Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Traditional Medicine, School of Medicine, University of Pecan, China.; Biochemistry of Nutritional Research Center, Avicenna Research Institute, Mashhad University of Medical Science, Mashhad, Iran.; Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran; Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: [email protected].; Institute for Science & Technology in Medicine, Faculty of Health, University of Keele, Staffordshire ST4 7QB, United Kingdom.; Biochemistry of Nutritional Research Center, Avicenna Research Institute, Mashhad University of Medical Science, Mashhad, Iran; Department of Nutrition and Nutritional Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: [email protected].; Department of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.

DOI: 10.1016/j.ctim.2014.04.004

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MeSH Terms: Adolescent, Adult, Aged, Bloodletting, C-Reactive Protein, HSP27 Heat-Shock Proteins, Heat-Shock Proteins, Humans, Medicine, Chinese Traditional, Metabolic Syndrome, Middle Aged, Molecular Chaperones, Young Adult