Is the Ami-AliA/B oligopeptide permease of Streptococcus pneumoniae involved in sensing environmental conditions?

J P Claverys, B Grossiord, G Alloing

Journal: Research in microbiology 2001;151(6):457-63

PMID: 10961459

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Abstract

Streptococcus pneumoniae is a fastidious obligate parasite requiring several amino acids for growth. Oligopeptide uptake mediated by the Ami ABC permease is therefore important for nutrition but this could not account for the highly pleiotropic phenotype exhibited by Ami mutants. The hypothesis that peptide transport plays a pivotal role in sensing environmental conditions and indirectly modulates the expression of several genes is discussed.

Address: Laboratoire de microbiologie et génétique moléculaire, UMR5100, CNRS-Université Paul Sabatier, Toulouse, France. [email protected]

DOI: 10.1016/s0923-2508(00)00169-8

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MeSH Terms: Bacterial Proteins, Carrier Proteins, DNA, Bacterial, Environment, Lipoproteins, Models, Genetic, Mutation, Phenotype, Regulatory Sequences, Nucleic Acid, Regulon, Streptococcus pneumoniae